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Phase 2 study examining magnesium-dependent tinnitus.

Michael J Cevette1, David M Barrs, Alpen Patel

  • 1Department of Otolaryngology, Mayo Clinis, Scottsdale, AZ, USA. Cevette.michael@mayo.edu

The International Tinnitus Journal
|January 18, 2012
PubMed
Summary

Magnesium supplementation may reduce tinnitus severity and handicap. This study found significant decreases in tinnitus distress and handicap scores after 3 months of daily magnesium intake.

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Area of Science:

  • Otolaryngology
  • Nutritional Neuroscience
  • Clinical Audiology

Background:

  • Emerging research suggests magnesium may alleviate noise-induced and idiopathic sensorineural hearing loss.
  • Epidemiological data reveal widespread magnesium deficiency in the American population.

Purpose of the Study:

  • To investigate the efficacy of supplemental magnesium in reducing tinnitus severity.
  • To assess the impact of magnesium on patient-reported tinnitus distress and handicap.

Main Methods:

  • Open-label, single-arm study involving 26 patients with moderate to very severe tinnitus.
  • Daily oral magnesium (532 mg) supplementation for 3 months.
  • Tinnitus severity assessed via Tinnitus Distress Rating (TDR) scale and Tinnitus Handicap Inventory (THI) converted to Tinnitus Severity Scale (TSS) grades.

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Main Results:

  • A significant decrease in tinnitus handicap (THI/TSS) was observed in subjects with slight or greater impairment (P=.03).
  • Patients reported a significant reduction in tinnitus severity post-intervention (P=.008).
  • Nineteen of 26 enrolled patients completed the study.

Conclusions:

  • Magnesium supplementation shows potential benefits for managing tinnitus-related handicap.
  • The findings suggest magnesium may positively influence the perception of tinnitus.