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Updated: May 25, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Prediction of sentinel lymph node positivity by growth rate of cutaneous melanoma
Antonio Tejera-Vaquerizo1, Eduardo Nagore, Enrique Herrera-Acosta
1Servicio de Dermatología, Hospital Virgen de la Victoria, Málaga, Spain. antoniotejera@aedv.es
Objective:
To determine whether growth rate (GR) of cutaneous melanoma predicts the histological sentinel lymph node (SLN) positivity.
Design:
Retrospective cohort study.
Setting:
Two tertiary melanoma referral centers.
Patients:
A total of 698 patients with invasive primary cutaneous melanoma in whom the SLN was identified between January 1, 2000, and June 30, 2010.
Main Outcome Measure:
Based on previous studies, a surrogate measure for GR in primary invasive melanoma was calculated as the ratio of Breslow thickness to time to melanoma development.
Results:
The SLN was positive in 20.2% of patients. Multivariate logistic regression analysis revealed that GR, Breslow thickness, and the presence of microscopic satellitosis were independently associated with SLN positivity. The probability of SLN positivity was 8.2% for slow-growth melanomas (<0.10 mm/mo) compared with 19.8% for intermediate-growth melanomas (0.10-0.50 mm/mo) and 37.7% for fast-growth melanomas (>0.50 mm/mo). Growth rate was not an independent predictive factor for survival.
Conclusion:
Growth rate of primary cutaneous melanoma, together with Breslow thickness and the presence of microscopic satellitosis, predicts the histological SLN positivity.
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