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A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
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Published on: January 27, 2019

Maternal sepsis: a Scottish population-based case-control study.

C D Acosta1, S Bhattacharya, D Tuffnell

  • 1National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK. colleen.acosta@npeu.ox.ac.uk

BJOG : an International Journal of Obstetrics and Gynaecology
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Obesity and operative vaginal delivery significantly increase the risk of maternal sepsis. Younger maternal age (<25 years) is also a key predictor of sepsis in pregnant women.

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Last Updated: May 25, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
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Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface
07:04

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface

Published on: July 21, 2016

Area of Science:

  • Obstetrics and Gynecology
  • Maternal Health
  • Infectious Diseases

Background:

  • Maternal sepsis remains a significant cause of morbidity and mortality worldwide.
  • Understudied risk factors for maternal sepsis require further investigation to improve clinical management.
  • Obesity is a growing public health concern with potential implications for pregnancy outcomes.

Purpose of the Study:

  • To investigate the association between obesity and maternal sepsis.
  • To identify other understudied risk factors for maternal sepsis, including operative vaginal delivery.
  • To provide evidence for improved clinical obstetric care and risk assessment.

Main Methods:

  • A population-based, case-control study was conducted in the North NHS region of Scotland.
  • Data were extracted from the Aberdeen Maternal and Neonatal Databank (AMND) from 1986 to 2009.
  • Multivariable logistic regression was used to analyze risk factors for uncomplicated and severe sepsis, adjusting for confounding variables.

Main Results:

  • Obese women had double the odds of uncomplicated sepsis (OR 2.12) compared to normal-weight women.
  • Younger maternal age (<25 years) (OR 5.15) and operative vaginal delivery (OR 2.20) were significant predictors of sepsis.
  • Established risk factors like multiparity, anemia, labor induction, cesarean section, and preterm birth also showed significant associations with sepsis.

Conclusions:

  • Obesity, operative vaginal delivery, and younger maternal age (<25 years) are identified as significant risk factors for maternal sepsis.
  • These findings underscore the importance of considering these factors in clinical obstetric care.
  • Further research and targeted interventions are warranted to mitigate the risk of maternal sepsis.