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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model Xiphophorus Provides Insights in Disease Control.

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Related Experiment Video

Updated: May 25, 2026

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish
07:16

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish

Published on: March 1, 2022

Small molecule screening identifies targetable zebrafish pigmentation pathways.

Sarah Colanesi1, Kerrie L Taylor, Nicholas D Temperley

  • 1Developmental Biology Programme, Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, UK.

Pigment Cell & Melanoma Research
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Researchers screened compounds to find those affecting zebrafish pigment cell development. They identified 57 compounds impacting melanocyte and iridophore development, offering new molecular tools for studying these cells.

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Large Scale Zebrafish-Based In vivo Small Molecule Screen

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Last Updated: May 25, 2026

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish
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A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
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Published on: November 8, 2014

Large Scale Zebrafish-Based In vivo Small Molecule Screen
07:03

Large Scale Zebrafish-Based In vivo Small Molecule Screen

Published on: December 30, 2010

Area of Science:

  • Developmental Biology
  • Zebrafish Research
  • Pharmacology

Background:

  • Small molecules are crucial for understanding pigment cell biology.
  • They can inhibit specific proteins or pathways to probe cellular functions.
  • Zebrafish serve as a valuable model organism for developmental studies.

Purpose of the Study:

  • To identify small molecules that modulate melanocyte and iridophore development in zebrafish.
  • To investigate the effects of these compounds on pigment cell biology.
  • To establish zebrafish as a model for testing drug activities.

Main Methods:

  • Screening of active compounds for effects on pigment cell development.
  • Confirmation of compounds affecting pigment cell patterning, number, survival, or differentiation.
  • Detailed investigation of selected compounds' effects.

Main Results:

  • Identified and confirmed 57 compounds altering pigment cell development.
  • Observed effects on pigment cell patterning, number, survival, and differentiation.
  • Discussed additional tissue targets and toxicity of the identified small molecules.

Conclusions:

  • The identified compounds serve as molecular tools for studying pigment cell development.
  • Zebrafish provide an in vivo system for assessing drug on- and off-target activities.
  • This research highlights the conservation of pigment cells across vertebrates.