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Updated: May 25, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Conformational stability studies of a stapled hexa-β3-peptide library
Romila D Gopalan1, Mark P Del Borgo, Ylva E Bergman
1School of Chemistry, Monash University, Clayton, VIC 3800, Australia.
Abstract:
A library of 14-helical hexa β(3)-peptides was synthesized in order to determine the influence of sequence variation as well as staple size and location on conformational stability. From this study we show that appropriately stapled hexa-β(3)-peptides can allow for a number of variations without significant perturbation of the 14-helix.
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