Related Experiment Video
Updated: May 25, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Regeneration of mastoid air cells using polycaprolactone/β-tricalcium phosphate biocomposites: an experimental study
Chul Ho Jang1, Yong Beom Cho, Jun Sung Kim
1Department of Otolaryngology, Chonnam National University Medical School, Research Center for Resistant Cells, Chosun Medical School, Gwangju, South Korea. chulsavio@hanmail.net
Objectives/Hypothesis:
The study aimed to regenerate pneumatic air cells in guinea pig bulla using three-dimenisonal (3D) biocomposite scaffolds consisting of polycaprolactone/β-tricalcium phosphate (PCL/β-TCP).
Study Design:
Prospective controlled study in experimental animals.
Methods:
PCL/β-TCP composites were implanted into the bulla with mucosa preservation in group A (n = 10). PCL/β-TCP composites coated with collagen were implanted in group B (n = 10). After 12 weeks, the bullae were extracted and evaluated by micro-computed tomography (micro-CT) and were processed for histological analyses.
Results:
In group A, micro-CT showed a well-maintained honeycomb appearance of micropores without obstruction. Regeneration of the mucosa was noted inside the pores of the 3D scaffold. However, partial obstruction of the micropores with new bone formation was evident in group B.
Conclusions:
Group A showed more satisfactory mucosal regeneration into the micropores. Our results indicate that the 3D scaffold may be amenable for use during mastoidectomy. Further studies for gas exchange in the regenerated mucosa are necessary.
