Modulation of the pentose phosphate pathway induces endodermal differentiation in embryonic stem cells

Genesia Manganelli1, Annalisa Fico, Ugo Masullo

  • 1Stem Cell Fate Lab, Institute of Genetics and Biophysics "A. Buzzati Traverso" CNR, Naples, Italy.

Plos One
|January 19, 2012
PubMed
Summary

Disrupting the Pentose Phosphate Pathway (PPP) in embryonic stem (ES) cells promotes endodermal differentiation. This metabolic insight offers new strategies for generating specific cell types for regenerative medicine.

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