Lipophilic compound-mediated gene expression and implication for intervention in reactive oxygen species
Yukiko K Nakamura1, Stanley T Omaye
1Department of Nutrition, University of Nevada, Reno, Nevada 89557-0208, USA. yukiko@cabnr.unr.edu
Abstract:
In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.
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