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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
What is the Cell Cycle?01:04

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?00:56

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...

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Updated: May 25, 2026

Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Analysis of cell cycle dynamics using probabilistic cell cycle models.

Evren Gurkan-Cavusoglu1, Jane E Schupp, Timothy J Kinsella

  • 1Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA. exg44@case.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Ionizing radiation alters cell cycle dynamics in colon cancer cells. Our probabilistic models show significant changes in the G1 and G2/M phases after treatment.

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Analysis of Cell Cycle Position in Mammalian Cells
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Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
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Area of Science:

  • Cell biology
  • Cancer research
  • Radiology

Background:

  • Cell cycle progression is crucial for cancer development.
  • Ionizing radiation is a common cancer treatment modality.
  • Understanding radiation's impact on cell cycle is vital for effective therapy.

Purpose of the Study:

  • To develop asynchronous probabilistic cell cycle models.
  • To quantitatively assess ionizing radiation's effects on human colon cancer cells.
  • To analyze changes in cell cycle phase durations post-treatment.

Main Methods:

  • Utilized both synchronous and asynchronous cell populations.
  • Modeled cell populations for up to two cell cycle times.
  • Employed probabilistic modeling for quantitative assessment.

Main Results:

  • Quantified alterations in cell cycle dynamics after ionizing radiation.
  • Identified significant changes in the duration of the G1 phase.
  • Observed notable changes in the duration of the G2/M phase.

Conclusions:

  • Asynchronous probabilistic models effectively assess radiation effects.
  • Ionizing radiation significantly impacts G1 and G2/M phase durations in colon cancer cells.
  • Findings provide insights into radiobiology and cancer treatment strategies.