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Updated: May 25, 2026

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Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
Published on: February 12, 2020
Micro-reaction chamber electrodes for neural stimulation and recording
Balaji Shanmugasundaram1, Bruce J Gluckman
1Department ofEngineering Science and Mechanics at the Pennsylvania State University, University Park, PA 16802, USA. s.balaji@psu.edu
Summary
New micro-reaction chamber (μRC) electrodes enhance neural recording and stimulation by improving charge storage and lowering impedance without changing the active site geometry.
Area of Science:
- Biomedical Engineering
- Electrophysiology
- Materials Science
Background:
- Biocompatible electrodes are crucial for neural recording and stimulation.
- Smaller electrode geometric areas enhance selectivity.
- Electrochemical reactions are key for charge passage in electrodes.
Purpose of the Study:
- Introduce a novel micro-reaction chamber (μRC) electrode design.
- Improve electrode performance by confining electrochemical reactions.
- Enhance charge storage capacity and reduce impedance.
Main Methods:
- Fabricated μRC electrodes using 50 μm diameter microwire.
- Confined electrochemical reactions within the electrode back plane.
- Measured impedance and charge storage capacity in phosphate buffered saline.
Main Results:
- μRC electrodes demonstrated significantly improved charge storage capacity.
- μRC electrodes exhibited lowered impedance at physiologically relevant frequencies.
- Performance improvements were achieved without altering the active site geometry.
Conclusions:
- The μRC electrode design offers enhanced performance for neural applications.
- This design provides a method to decrease impedance and increase charge storage.
- μRC electrodes represent a promising advancement in neural interface technology.

