Related Experiment Video
Updated: May 25, 2026
The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
Published on: July 26, 2024
Chronic behavior evaluation of a micro-machined neural implant with optimized design based on an experimentally
Alexandru Andrei1, Marleen Welkenhuysen, Lieveke Ameye
1Bioelectronic Systems Group, Imec, 3001 Heverlee, Belgium. andreial@imec.be
Abstract:
Understanding the mechanical interactions between implants and the surrounding tissue is known to have an important role for improving the bio-compatibility of such devices. Using a recently developed model, a particular micro-machined neural implant design aiming the reduction of insertion forces dependence on the insertion speed was optimized. Implantations with 10 and 100 μm/s insertion speeds showed excellent agreement with the predicted behavior. Lesion size, gliosis (GFAP), inflammation (ED1) and neuronal cells density (NeuN) was evaluated after 6 week of chronic implantation showing no insertion speed dependence.
