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Updated: May 25, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Malherbe's calcifying epithelioma (pilomatrixoma)--own experience]
Ewa Czerniawska1, Arkadiusz Pogrzebielski, Bozena Romanowska-Dixon
1Z Katedry i Kliniki Okulistyki i Onkologii Okulistycznej Uniwersytetu Jagiellońskiego Collegium Medicum w Krakowie.
Purpose:
Malherbe's calcifying epithelioma is a rare hair matrix tumor. The objective is to present clinical cases and to analyze the variability of its image.
Material And Methods:
Among nearly 3500 patients with ocular tumors operated during the last 10 years in the Department of Ophthalmology and Ocular Oncology in Krakow we identified a group of 7 patients with histologically confirmed pilomatrixoma. A retrospective evaluation of their medical history was performed, paying particular attention to the co-existence of other diseases, form of growth and location of tumors, as well as treatment methods and their effectiveness. The results were compared with other clinical studies.
Results:
Malherbe's calcifying epithelioma is characterized by clinical polymorphism and similarity to other much more frequent eyelid tumors. It usually has the form of a single, small, movable, slowly growing nodule covered by intact skin. In addition to the classic form described there are pediculated tumors, huge, fast-growing, perforating, as well as tumors in unusual locations and multiple lesions.
Conclusions:
The consequences of variation pilomatrixoma are clinical diagnostic errors. The one, sure and reliable criterion is a histopathology evaluation.
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