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Related Experiment Video

Updated: May 25, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Olanzapine-induced eccrine squamous syringometaplasia.

Ana María Molina-Ruiz¹, Rosa Maria Molina-Ruiz, Teresa Zulueta

¹Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain. anamolina6@hotmail.com

The American Journal of Dermatopathology

|January 20, 2012

Summary

Eccrine squamous syringometaplasia, a rare skin reaction, was observed in a patient treated with olanzapine, an antipsychotic medication. This case highlights a potential non-chemotherapy drug association with this histopathologic pattern.

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Last Updated: May 25, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

Dermatopathology
Pharmacology
Oncology

Background:

Eccrine squamous syringometaplasia (ESS) is a recognized histopathologic finding.
ESS is predominantly associated with chemotherapy agents.
Reports linking ESS to non-chemotherapeutic agents are infrequent.

Observation:

A 55-year-old patient diagnosed with schizophrenia was initiated on olanzapine treatment.
The patient developed a distinct skin eruption approximately five weeks after starting olanzapine.
Histopathologic examination of the skin lesions was performed.

Findings:

The histopathologic study confirmed the presence of squamous syringometaplasia.
The syringometaplasia specifically affected the dermal eccrine ducts.
This finding represents a rare association between olanzapine and ESS.

Implications:

This case expands the known spectrum of drug-induced skin reactions.
It suggests olanzapine as a potential, albeit rare, trigger for ESS.
Further investigation may be warranted to understand the mechanism of ESS in non-chemotherapy contexts.