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A cell-based backup to speed up pandemic influenza vaccine production

Min-Shi Lee1, Alan Yung-Chih Hu

  • 1National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350, Taiwan. minshi@nhri.org.tw

Trends in Microbiology
|January 20, 2012
PubMed

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Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...