Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis.
Tomoyoshi Aoyagi1, Kiyohiko Shuto, Shinichi Okazumi
1Department of Frontier Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan. aotomo@d2.dion.ne.jp
European Radiology
|January 20, 2012
Summary
Apparent diffusion coefficient (ADC) values in oesophageal squamous cell carcinoma (ESCC) inversely correlate with stromal collagen and vascular endothelial growth factor (VEGF). Lower ADC values indicate increased collagen and VEGF, suggesting ADC as a potential prognostic factor for ESCC treatment.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Diffusion-weighted imaging (DWI) aids in predicting oesophageal squamous cell carcinoma (ESCC) prognosis.
- Apparent diffusion coefficient (ADC) values may reflect tumour microenvironment characteristics like collagen content and angiogenesis.
Purpose of the Study:
- To investigate the correlation between pre-treatment ADC values in ESCC and tumour stroma characteristics, specifically collagen content and angiogenesis.
Main Methods:
- Seventeen ESCC patients underwent DWI for ADC value calculation.
- Tumour stroma, collagen content (azocarmine and aniline blue staining), vascular endothelial growth factor (VEGF), and CD34 expression were analyzed post-oesophagectomy.
Main Results:
- A significant negative correlation was observed between tumour ADC values and stromal collagen content (r = -0.729, P = 0.001).
- ADC values also showed a negative correlation with VEGF levels (r = 0.538, P = 0.026), indicating decreased ADC with increased VEGF.
Conclusions:
- ADC values are inversely related to tumour stromal collagen and VEGF levels in ESCC.
- ADC may serve as a novel prognostic biomarker for oesophageal cancer, potentially guiding treatment strategies.
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