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Statistical characteristics of finger-tapping data in Huntington's disease

Chrystalina A Antoniades1, Jan Ober, Stephen Hicks

  • 1Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Chrystalina.antoniades@clneuro.ox.ac.uk

Medical & Biological Engineering & Computing
|January 20, 2012
PubMed
Summary

Finger tapping analysis, beyond simple rate, reveals neurological impairment in Huntington

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...