Related Experiment Video
Updated: May 25, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
2-(5-Fluoro-2,3-dioxoindolin-1-yl)ethyl 4-methyl-piperazine-1-carbodithio-ate
Yao Wang1, Hui-Hui Lin, Sheng-Li Cao
1Department of Chemistry, Capital Normal University, Beijing 100048, People's Republic of China.
Abstract:
In the title compound, C(16)H(18)FN(3)O(2)S(2), the methyl-piperazine ring adopts a chair conformation, while the (2,3-dioxoindolin-1-yl)ethyl unit is linked to one of the N atoms of the piperazine ring via the carbodithio-ate group. In the crystal, each mol-ecule is linked to its neighbors within the ([Formula: see text]03) plane through weak C-H(methyl-ene)⋯O, C-H(ar-yl)⋯O and C-H(methyl-ene)⋯S inter-actions. Perpendicular to this plane mol-ecules are connected through inter-molecular short N⋯π(pyrrole ring) contacts [N⋯C centroid = 3.232 (2) Å], another set of C-H(methyl-ene)⋯O inter-actions and through short contacts between carbodithio-ate S atoms and the pyrrole rings [C⋯centroid = 3.695 (3), S⋯centroid = 3.403 (2) Å].

