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Updated: May 25, 2026
06:09
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Dandy-walker malformation associated with neurocutaneous melanosis
In Yong Cho1, Sung-Kyun Hwang, Sung-Hak Kim
1Department of Neurosurgery, College of Medicine, Ewha Womans University, Seoul, Korea.
Journal of Korean Neurosurgical Society
|January 20, 2012
Summary
Neurocutaneous melanosis with Dandy-Walker malformation is a rare congenital disorder. This case study presents a 2-month-old infant, exploring the condition's pathogenesis.
Area of Science:
- Neuroscience
- Developmental Biology
- Genetics
Background:
- Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the abnormal proliferation of melanocytes.
- It is frequently associated with central nervous system (CNS) abnormalities and large pigmented skin lesions (nevi).
- Dandy-Walker malformation (DWM) is a congenital brain malformation affecting cerebellar development.
Observation:
- This report details a rare case of NCM co-occurring with DWM in a 2-month-old infant.
- The patient presented with clinical features consistent with both NCM and DWM.
Findings:
- The co-occurrence of NCM and DWM represents a complex dysmorphogenesis.
- The study reviews existing literature to understand the potential shared etiological factors and developmental pathways.
Implications:
- Understanding the pathogenesis of this rare association is crucial for accurate diagnosis and management.
- Further research into the genetic and molecular underpinnings may reveal therapeutic targets.
- This case highlights the importance of recognizing rare syndromic associations in pediatric neurology.
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