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[Study on the pharmacokinetics Oxytropis falcate total flavonoids ointment in rats]
Wei-Dong Li1, Zhi-Peng Chen, Min-Ming Qu
1Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing 210029, China.
Objective:
To study the pharmacokinetics of Oxytropis falcate total flavonoids ointment after transdermal administration in rats.
Methods:
The content of 2',4'-dihydroxychalcone (TFC) in plasma was determined by high performance liquid chromatography. The concentration was determined at various time and the data was processed by 3P97.
Results:
TFC behaved as a one-compartment and a two-compartment model after transdermal administration of total Oxytropis falcate total flavonoids ointment and solution, respectively. And the C(max) of ointment was improved about 3 times compared with that of the solution.
Conclusion:
The results show that the ointment possesses sustained release property and significantly prolong the degradation half life of TFC. The ointment is benefit to improve the analgesic and anti-inflammatory activity after transdermal administration.
