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Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
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Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

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[Postoperative changes of immunity in children undergoing adenoidectomy with tonsil ablation or with partial

Chengyong Zhou1, Zhiyao Dai

  • 1Department of Otolaryngology, First Affiliated Hospital of PLA General Hospital, Beijing 100048, China. zhcyong@bbn.cn

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|January 21, 2012
PubMed

Insights

Pediatric obstructive sleep apnea surgery (adenoidectomy with tonsil ablation or partial tonsillectomy) does not significantly impact humoral or cellular immunity. Immune function in children with OSAHS returns to normal levels within three months post-operation.

Area of Science:

  • Immunology
  • Otolaryngology
  • Pediatric Surgery

Background:

  • Obstructive sleep apnea-hypopnea syndrome (OSAHS) in children often necessitates surgical intervention.
  • Tonsillectomy and adenoidectomy are common procedures, with varying techniques impacting surrounding tissues.
  • Understanding the immunological consequences of these procedures is crucial for pediatric patient care.

Purpose of the Study:

  • To compare the effects of adenoidectomy with tonsil ablation versus partial tonsillectomy on humoral and cellular immunity in children with OSAHS.
  • To evaluate the temporal changes in immune responses following these surgical interventions.

Main Methods:

  • Seventy children diagnosed with OSAHS were divided into two surgical groups: adenoidectomy with tonsil ablation and adenoidectomy with partial tonsillectomy.
  • Peripheral venous blood samples were collected pre-operatively and at one and three months post-operatively.
  • Serum immunoglobulin (IgG, IgA, IgM) levels and peripheral blood T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+ ratio) were analyzed.

Main Results:

  • Both surgical groups showed transient, minor fluctuations in T lymphocyte subsets at one month post-operation, with no significant inter-group differences.
  • Serum immunoglobulin levels remained largely unchanged and did not differ significantly between the two groups.
  • Immune parameters in both groups returned to baseline preoperative levels by three months after surgery.

Conclusions:

  • Adenoidectomy with tonsil ablation or partial tonsillectomy, using plasma-mediated radiofrequency ablation, does not adversely affect humoral or cellular immunity in children with OSAHS.
  • The immune system demonstrates resilience, with immune function normalizing within three months post-surgery, regardless of the tonsillectomy technique used.
Abstract

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