Related Experiment Video
Updated: May 25, 2026
07:41
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Delving into somatic variation in sporadic melanoma
Vijay Walia1, Euphemia W Mu, Jimmy C Lin
1The Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Pigment Cell & Melanoma Research
|January 21, 2012
Summary
Genomic research has advanced our understanding of melanoma, the deadliest skin cancer. New sequencing technologies are identifying therapeutic targets for personalized melanoma treatments.
Area of Science:
- Oncology
- Genomics
- Dermatology
Background:
- Melanoma incidence is rapidly increasing, making it a significant public health concern.
- Understanding the genetic basis of melanoma is crucial for developing effective treatments.
Purpose of the Study:
- To review the historical and current genomic approaches used to study melanoma.
- To highlight the impact of advanced sequencing technologies on melanoma research.
Main Methods:
- Survey of historical research methodologies in melanoma genomics.
- Analysis of advancements in whole-exome and whole-genome sequencing.
Main Results:
- Genomic studies have evolved from candidate genes to comprehensive genome-wide analyses.
- Next-generation sequencing has provided unprecedented depth in understanding melanoma genetics.
Conclusions:
- Advanced genomic insights are crucial for identifying new therapeutic targets in melanoma.
- Personalized therapies for melanoma are becoming increasingly feasible due to genomic advancements.
Related Concept Videos
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...