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CTRP family: linking immunity to metabolism
Andreas Schäffler1, Christa Buechler
1Department of Internal Medicine I, Regensburg University Medical Center, D-93042 Regensburg, Germany. andreas.schaeffler@klinik.uni-regensburg.de
Trends in Endocrinology and Metabolism: TEM
|January 21, 2012
Summary
The C1q/TNF-related protein (CTRP) family, including adiponectin, links inflammatory and metabolic diseases. These proteins offer potential therapeutic targets for conditions like sepsis, diabetes, and obesity.
Area of Science:
- Biochemistry
- Immunology
- Metabolic Science
Background:
- Infectious and inflammatory diseases (e.g., sepsis) involve metabolic changes like insulin resistance.
- Metabolic diseases (e.g., type 2 diabetes) feature elevated proinflammatory cytokines.
- Metabolism and immunity are interconnected through dual-function proteins.
Purpose of the Study:
- To review the biochemistry and physiological functions of CTRP family members.
- To highlight CTRPs as novel molecular mediators linking inflammatory and metabolic diseases.
- To explore the role of adiponectin and other CTRPs in health and disease.
Main Methods:
- Literature review of studies on CTRP family proteins.
- Analysis of biochemical properties and physiological roles of CTRPs.
- Synthesis of current knowledge on CTRPs in metabolism and immunity.
Main Results:
- Adiponectin, a CTRP, exhibits anti-inflammatory and insulin-sensitizing effects.
- Fifteen additional CTRP family members have been identified.
- CTRPs are implicated as key players in the interplay between metabolic and inflammatory pathways.
Conclusions:
- CTRPs represent a crucial link between metabolic and inflammatory processes.
- Adiponectin and other CTRPs are potential therapeutic targets for metabolic and inflammatory disorders.
- Further research into CTRP functions can elucidate novel treatment strategies.
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