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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.

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Related Experiment Video

Updated: May 25, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Cell cycle synchronization by nutrient modulation.

Yuan Tian1, Chunxiong Luo, Yuheng Lu

  • 1Center for Microfluidic and Nanotechnology, The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, 100871, China.

Integrative Biology : Quantitative Biosciences From Nano to Macro
|January 21, 2012
PubMed
Summary
This summary is machine-generated.

Yeast cell division synchronizes with nutrient availability. Optimized periodic nutrient changes can synchronize up to 80% of cells, offering a novel method for cell cycle control.

More Related Videos

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Related Experiment Videos

Last Updated: May 25, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Area of Science:

  • Cell Biology
  • Microbiology
  • Biophysics

Background:

  • Cellular activities, including the cell division cycle, are regulated by environmental cues like nutrient availability.
  • The precise coupling between nutrient levels and cell cycle timing in unicellular organisms remains incompletely understood.
  • Intrinsic timescales of cell cycle processes under dynamic nutrient conditions require further investigation.

Purpose of the Study:

  • To investigate the cell cycle behavior of budding yeast (Saccharomyces cerevisiae) under periodically modulated nutrient availability.
  • To determine the extent to which cell division can be synchronized with external nutrient fluctuations.
  • To explore a potential non-invasive method for continuous cell cycle synchronization.

Main Methods:

  • Utilized a microfluidic platform for long-term cultivation of yeast.
  • Implemented programmed medium switching to create periodic nutrient modulations.
  • Employed automated time-lapse microscopy for real-time cell cycle monitoring.

Main Results:

  • Observed that the yeast cell division cycle can follow periodic nutrient modulation, leading to population synchrony.
  • Achieved continuous synchronization of up to 80% of the cell population under optimized modulation periods.
  • Developed a stochastic phenomenological model that qualitatively captures the synchronization degree as a function of modulation period.

Conclusions:

  • Demonstrated a strong coupling between cell growth, cell division, and nutrient availability in yeast.
  • Established a non-toxic and non-invasive method for achieving continuous cell cycle synchronization in a population.
  • Provided insights into the dynamic regulation of the cell cycle in response to environmental periodicity.