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A universal strategy for preparing protected C-terminal peptides on the solid phase through an intramolecular click
Miriam Góngora-Benítez1, Michèle Cristau, Matthieu Giraud
1Institute for Research in Biomedicine, Barcelona Science Park (PCB), Baldiri Reixac 10, 08028-Barcelona, Spain.
Chemical Communications (Cambridge, England)
|January 21, 2012
Abstract:
A new universal strategy exploits DKP formation in a dipeptide moiety whose C-terminal residue is blocked by a leaving group. It enables both synthesis of C-terminal protected peptides that are useful for convergent synthesis of large peptides and use of a C-terminal permanent protecting group that can be cleaved by catalytic hydrogenation to release the peptide.
