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Microcircuits mediating feedforward and feedback synaptic inhibition in the piriform cortex.

Norimitsu Suzuki¹, John M Bekkers

¹Department of Neuroscience, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|January 21, 2012

Summary

Local inhibition in the olfactory cortex is crucial for processing sensory information. This study reveals distinct feedforward and feedback inhibitory circuits involving specific neuron types in the piriform cortex.

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Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Published on: January 10, 2015

Area of Science:

Neuroscience
Olfactory System Research
Cortical Circuitry

Background:

Local inhibition by GABA-releasing neurons is vital for sensory cortex function.
The precise details of inhibitory circuits in the olfactory system remain largely uncharacterized.

Purpose of the Study:

To elucidate the connectivity and function of inhibitory microcircuits in the mouse piriform cortex (PC).
To differentiate between feedforward and feedback synaptic inhibition mechanisms.
To identify the specific neuronal classes responsible for these inhibitory processes.

Main Methods:

Targeted electrophysiological recordings from identified inhibitory and glutamatergic neurons in the mouse PC.
Layer I tissue dissection to isolate feedback inhibition.
Dynamic clamp simulations to model inhibitory effects.

Main Results:

Identified two types of feedforward inhibition in layer Ia: fast, restricted inhibition by horizontal cells and slow, diffuse inhibition by neurogliaform cells, both targeting layer II principal neurons.
Discovered powerful feedback inhibition of layer II neurons, primarily mediated by layer III fast-spiking multipolar cells driven by layer II semilunar cells.
Dynamic clamp revealed differential impacts of feedback inhibition on distinct layer II principal neuron types.

Conclusions:

The study delineates the specific roles and connectivity of horizontal cells, neurogliaform cells, and fast-spiking multipolar cells in PC inhibitory microcircuits.
Both feedforward and feedback inhibition are essential for olfactory information processing in the piriform cortex.