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Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: May 25, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

[Vascular endothelial growth factor].

R Kaiser¹, P Dubový, P Haninec

¹Univerzita Karlova v Praze, 3. lékarská fakulta a FN Královské Vinohrady, Neurochirurgická klinika, Praha. kaiser@fnkv.cz

Ceskoslovenska Fysiologie

|January 24, 2012

Summary

This summary is machine-generated.

Vascular Endothelial Growth Factor (VEGF) promotes new blood vessel growth and supports nerve health. This vital substance, initially linked to tumors, plays a broader role in tissue repair and regeneration than previously understood.

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Area of Science:

Molecular Biology
Oncology
Neuroscience

Context:

Vascular Endothelial Growth Factor (VEGF) was first identified in 1983 as a tumor-secreted protein.
VEGF's role in angiogenesis (new blood vessel formation) is well-established.
Hypoxia is a primary driver for increased VEGF production and subsequent angiogenesis.

Purpose:

To review the multifaceted roles of VEGF beyond its initial description.
To highlight the neuroprotective and proliferative effects of VEGF on the nervous system.
To underscore the expanding understanding of VEGF's biological functions.

Summary:

VEGF, initially known for inducing ascitic fluid in abdominal tumors, significantly influences angiogenesis.
First noted in 1999, VEGF exhibits protective and proliferative effects on both central and peripheral nervous systems.
Recent findings indicate that VEGF possesses a more extensive range of biological activities than previously recognized.

Impact:

Expands the understanding of VEGF's therapeutic potential in various medical conditions.
Provides a foundation for further research into VEGF-mediated pathways in both cancer and neurological disorders.
Emphasizes the importance of VEGF in tissue homeostasis and repair mechanisms.