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Prehospital Thrombolysis: A Manual from Berlin

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Published on: November 26, 2013

Our experience with thrombolytic therapy -- preliminary report.

Sinisa Miljković¹, Tamara Rabi-Zikić, Milan Arbutina

¹University Department of Neurology, Banjaluka Clinical Center, Banjaluka, Republika Srpska, Bosnia and Herzegovina. neurologija@blic.net

Acta Clinica Croatica

|January 24, 2012

Summary

Thrombolytic therapy effectively treats ischemic stroke within three hours of symptom onset. This study found 95% survival and significant recovery in patients receiving this critical intervention.

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An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Area of Science:

Neurology
Vascular Medicine
Emergency Medicine

Background:

Stroke is a leading cause of death and disability, characterized by acute cerebral dysfunction of vascular origin.
Ischemic stroke, a major subtype, presents a significant clinical challenge due to its rapid progression.
Effective treatments are crucial for improving patient outcomes and reducing long-term deficits.

Purpose of the Study:

To report preliminary findings on the efficacy and safety of thrombolytic therapy in patients with ischemic stroke.
To evaluate the outcomes of patients treated within a critical time window.
To assess the role of thrombolytic therapy as a primary treatment option.

Main Methods:

A cohort of 20 patients with ischemic stroke received thrombolytic therapy within three hours of symptom onset.
Patient survival, causes of mortality, and neurological status were monitored.
Functional outcomes were assessed using the Rankin scale at three months post-stroke.

Main Results:

Nineteen out of 20 patients survived the treatment.
One patient mortality was attributed to intracerebral hematoma, a known side effect.
Seventeen survivors had no neurological deficit; two experienced minimal disability (Rankin score 2).

Conclusions:

Thrombolytic therapy demonstrates high efficacy and a favorable survival rate in acute ischemic stroke.
Early administration within three hours is critical for successful outcomes.
Adherence to precise protocols ensures the safe and effective use of thrombolytic therapy.