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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Published on: January 19, 2016

Diverse trifluoromethyl heterocycles from a single precursor

Mark A Honey1, Raffaele Pasceri, William Lewis

  • 1School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

The Journal of Organic Chemistry
|January 24, 2012
PubMed
Summary

Ethyl 2-diazo-4,4,4-trifluoro-3-oxobutanoate is a key intermediate for synthesizing trifluoromethyl heterocycles. Rhodium or copper catalysis enables efficient access to diverse oxazoles, thiazoles, imidazoles, triazines, and pyridines.

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