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Related Experiment Video

Updated: May 25, 2026

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
12:16

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Published on: May 18, 2015

Tissue-engineered oral mucosa.

K Moharamzadeh1, H Colley, C Murdoch

  • 1School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, UK. k.moharamzadeh@sheffield.ac.uk

Journal of Dental Research
|January 24, 2012
PubMed
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Tissue engineering advances enable 3D reconstruction of human oral mucosa for diverse applications. These engineered tissues are vital for treating defects, modeling diseases, and evaluating dental materials.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Oral Biology

Background:

  • Tissue engineering has enabled the creation of three-dimensional (3D) human oral mucosa.
  • Recent advancements focus on optimizing these constructs for clinical use as grafts for soft-tissue repair.
  • These engineered tissues offer alternatives to animal models for studying oral diseases and drug delivery.

Purpose of the Study:

  • To review recent progress in tissue engineering of human oral mucosa.
  • To highlight the diverse applications of engineered oral mucosa.
  • To discuss the impact on biocompatibility testing and implant research.

Main Methods:

  • Review of current literature on 3D oral mucosal tissue engineering.
  • Analysis of applications in regenerative medicine and disease modeling.

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Last Updated: May 25, 2026

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
12:16

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Published on: May 18, 2015

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

  • Evaluation of the role in biocompatibility and implant interface studies.

    • Main Results:

    • Engineered oral mucosa is suitable for intra-oral and extra-oral repair.
    • Novel 3D models facilitate research on oral cancer, Candida, and bacterial invasion.
    • Significant impact on biocompatibility testing of dental materials and oral healthcare products.
    • Advancements in studying implant-soft tissue interfaces.

    Conclusions:

    • Tissue-engineered human oral mucosa represents a significant advancement in regenerative medicine.
    • These constructs have broad applications in clinical repair, disease modeling, and material evaluation.
    • Future research will likely expand their use in personalized medicine and advanced oral healthcare solutions.