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Calciotropic hormones and the aging bone.

P Burckhardt1

  • 1Department of Internal Medicine, University Hospital-CHUV, Lausanne, Switzerland.

Experimental Gerontology
|January 1, 1990
PubMed
Summary
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Bone aging involves structural changes, reduced cellular activity, and fewer hormone receptors, impacting calcium metabolism. This age-related decline affects how the body processes calcium and vitamin D, influencing hormonal actions.

Area of Science:

  • Gerontology
  • Bone Biology
  • Calcium Metabolism

Background:

  • Bone aging is influenced by intrinsic and extrinsic factors.
  • Age-related bone loss includes decreased density, cortical, and trabecular bone volume.
  • Interstitial bone increases with age, exhibiting lower cellularity and metabolic activity.

Purpose of the Study:

  • To explore the impact of aging on bone structure and cellular function.
  • To understand how age-related changes affect the calcium metabolism pathway.
  • To investigate the reduced efficacy of calciotropic hormones in older individuals.

Main Methods:

  • Review of existing literature on bone aging and calcium metabolism.
  • Analysis of structural changes in bone tissue with age.

Related Experiment Videos

  • Examination of the interplay between aging, vitamin D, and calciotropic hormones.

    • Main Results:

    • Bone aging is characterized by decreased bone density and volume, alongside increased interstitial bone.
    • Reduced bone cellularity, activity, and hormonal receptor availability occur with age.
    • The aging process can disrupt multiple steps in calcium and vitamin D metabolism.

    Conclusions:

    • Age-related structural bone changes reduce the target organ's responsiveness to calciotropic hormones.
    • The aging bone's diminished cellular and metabolic activity impacts calcium homeostasis.
    • Aging significantly interferes with the entire calcium and vitamin D regulatory system.