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Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
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Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and

Alberto Curcio1, Roberto Marotta, Andreas Riedinger

  • 1Istituto Italiano di Tecnologia, via Morego 30, 161613, Genoa, Italy.

Chemical Communications (Cambridge, England)
|January 24, 2012
PubMed

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...