Related Experiment Video
Updated: May 25, 2026
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Improved outcomes in buccal squamous cell carcinoma
Chun-Shu Lin1, Yee-Min Jen, Woei-Yau Kao
1Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. chunshulin@gmail.com
Background:
The treatment results of buccal squamous cell carcinoma before and after 2002 were compared.
Methods:
Two hundred forty-five patients with buccal cancer who underwent curative treatment were retrospectively reviewed.
Results:
The 5-year overall survival rate was 30.0% before 2002 and 53.5% after 2002 (p = .004). On multivariate analysis, T classification, surgical margins, and treatment modality significantly affected overall survival, and N classification and histologic grade had trends to affect it. Invasion depth had a trend to influence locoregional control. For patients with early-stage disease without adverse factors, the locoregional control was similar between surgery alone group and surgery + radiotherapy group.
Conclusion:
The survival of patients with buccal cancer was improved after 2002, which represented the start of intensity-modulated radiotherapy (IMRT) in our institute. Ipsilateral neck alone irradiation was recommended for T1-2N0-1 and small T3N0 disease, and bilateral neck irradiation could be reserved for advanced disease.
