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Updated: Sep 9, 2026

A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt
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A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt

Published on: June 22, 2011

Transdifferentiation of larval Xenopus laevis iris under the influence of the pituitary

C Cioni1, L Bosco, S Filoni

  • 1Department of Animal and Human Biology, La Sapienza University, Rome, Italy.

Experientia
|October 15, 1990
PubMed

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Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...