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Cardio-ventilatory coupling in young healthy resting subjects
Lee Friedman1, Thomas E Dick, Frank J Jacono
1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. lfriedman10@gmail.com
Cardio-ventilatory coupling (CVC) is strongest between R-waves and inspiration onset (R-to-I interval). This R-to-I coupling is a reliable subject trait, independent of respiratory sinus arrhythmia (RSA).
Area of Science:
- Cardiorespiratory physiology
- Systems biology
- Biomedical engineering
Background:
- Cardio-ventilatory coupling (CVC) describes the statistical relationship between respiratory events and heartbeats.
- Understanding CVC is crucial for assessing autonomic nervous system function.
Purpose of the Study:
- To quantify CVC in healthy young adults.
- To determine the reliability and influencing factors of CVC measures.
- To investigate the relationship between CVC and respiratory sinus arrhythmia (RSA).
Main Methods:
- Assessed CVC in 19 healthy young subjects using transformed relative Shannon entropy (tRSE).
- Analyzed four intervals: R-to-I, I-to-R, R-to-E, and E-to-R.
- Computed test-retest reliability over 5–27 days and correlated CVC with anthropometric data.
Main Results:
- CVC was significantly stronger and more reliable in the R-to-I interval.
- R-to-I interval CVC correlated with height, weight, and body surface area.
- CVC in the R-to-I interval was independent of RSA measures.
Conclusions:
- The R-to-I interval is the most significant measure for CVC assessment.
- CVC strength, particularly in the R-to-I interval, appears to be a stable subject trait.
- CVC and RSA represent distinct physiological coupling mechanisms.
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