Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Partial hepatectomy and mediators of inflammation decrease the expression of liver alpha 2-HS glycoprotein gene in

M Daveau1, C Davrinche, N Djelassi

  • 1INSERM Unité 78, BP 73, 76233 Bois-Guillaume, France.

FEBS Letters
|October 29, 1990
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interpretation and classification of FBN1 variants associated with Marfan syndrome: consensus recommendations from the Clinical Genome Resource's FBN1 variant curation expert panel.

Genome medicine·2024
Same author

De Novo Balanced Translocations Disrupting the FBN1 Gene Diagnosed by Genome Sequencing: An Uncommon Cause of Marfan Syndrome Modifying Genetic Counseling.

American journal of medical genetics. Part A·2024
Same author

Perioperative infectious risk in urology: Management of preoperative polymicrobial urine culture. A systematic review. By the infectious disease Committee of the French Association of urology.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2019
Same author

Evaluation of broad-spectrum beta-lactam prescriptions (except carbapenems) in a French teaching hospital.

Medecine et maladies infectieuses·2018
Same author

Pyelonephritis in Dogs: Retrospective Study of 47 Histologically Diagnosed Cases (2005-2015).

Journal of veterinary internal medicine·2017
Same author

Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis.

Arthritis research & therapy·2017

Acute phase response in rats significantly decreases alpha 2-HS glycoprotein mRNA levels. This down-regulation of gene expression is observed following inflammation or partial hepatectomy, impacting this major negative acute phase reactant (APR).

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Acute phase reactants (APRs) are proteins whose plasma concentrations change significantly in response to inflammation.
  • Alpha 2-HS glycoprotein is a major negative APR, while alpha 1-acid glycoprotein is a major positive APR.
  • Understanding the regulation of APR gene expression is crucial for comprehending the inflammatory response.

Purpose of the Study:

  • To investigate the regulation of alpha 2-HS glycoprotein and alpha 1-acid glycoprotein mRNA levels during the acute phase response in rat liver.
  • To determine if inflammatory mediators and partial hepatectomy affect the gene expression of these APRs.

Main Methods:

  • Measurement of liver mRNA levels of alpha 2-HS glycoprotein and alpha 1-acid glycoprotein in male rats.

Related Experiment Videos

  • Induction of acute phase response using turpentine or tumor necrosis factor administration.
  • Induction of acute phase response via partial hepatectomy.

    • Main Results:

    • A significant decrease in alpha 2-HS glycoprotein mRNA levels was observed in all experimental conditions, peaking at 24 hours.
    • A concurrent increase in alpha 1-acid glycoprotein mRNA levels was noted under the same conditions.
    • These changes indicate differential regulation of gene expression for negative and positive APRs.

    Conclusions:

    • The acute phase response, triggered by inflammatory mediators or partial hepatectomy, leads to down-regulation of alpha 2-HS glycoprotein gene expression in rat liver.
    • The observed changes in mRNA levels reflect the distinct roles of alpha 2-HS glycoprotein as a negative APR and alpha 1-acid glycoprotein as a positive APR during inflammation.