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Acute kidney injury in children and its potential consequences in adulthood

Stuart L Goldstein1

  • 1Center for Acute Care Nephrology, Division of Nephrology and Hypertension, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45206, USA. stuart.goldstein@cchmc.org

Blood Purification
|January 25, 2012
PubMed

Insights

Pediatric acute kidney injury (AKI) is increasing, with changing causes. This review examines AKI

Area of Science:

  • Pediatric Nephrology
  • Renal Medicine
  • Public Health

Background:

  • Rising incidence of pediatric acute kidney injury (AKI) and chronic kidney disease (CKD).
  • Evolving etiologies of kidney disease in children.
  • Limited understanding of the AKI to CKD transition in pediatric populations.

Purpose of the Study:

  • Review the changing epidemiology of pediatric AKI.
  • Investigate the potential impact of AKI on the development of CKD in children.

Main Methods:

  • Review of recent data and literature on pediatric AKI.
  • Analysis of validated multidimensional AKI classification systems for children.
  • Examination of chronic kidney sequelae in at-risk pediatric populations.

Main Results:

  • Emerging evidence suggests a growing trend in pediatric AKI and CKD.
  • New classification systems aid in understanding AKI.
  • Studies are investigating long-term outcomes in children with AKI or at risk.

Conclusions:

  • Early intervention is crucial for improving outcomes in pediatric kidney disease.
  • Further research is needed to understand and prevent AKI progression to CKD in children.

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