Related Experiment Video

Updated: May 25, 2026

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer
06:19

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Published on: July 18, 2017

Rottlerin and cancer: novel evidence and mechanisms

E Maioli1, C Torricelli, G Valacchi

  • 1Department of Physiology, University of Siena, Aldo Moro Street, 53100 Siena, Italy. maioli@unisi.it

Thescientificworldjournal
|January 25, 2012
PubMed

Insights

Rottlerin, a plant-derived compound, shows promise as an anticancer agent by targeting multiple cellular pathways involved in cancer progression. Its multifaceted effects on survival, apoptosis, autophagy, and invasion warrant further investigation for cancer treatment.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Oncology

Background:

  • Cancer arises from the deregulation of numerous genes, necessitating anticancer agents that target multiple pathways.
  • Plant-derived compounds are increasingly recognized for their therapeutic potential in cancer chemotherapy.
  • Rottlerin is a natural compound exhibiting significant anticancer properties.

Purpose of the Study:

  • To summarize the multifocal signal modulatory properties of Rottlerin.
  • To highlight Rottlerin's potential for cancer prevention and treatment.
  • To explore Rottlerin's effects on multiple cancer-related cellular processes.

Main Methods:

  • Literature review of studies investigating Rottlerin's effects on cancer cells.
  • Analysis of Rottlerin's impact on signaling pathways.
  • Examination of Rottlerin's influence on apoptosis, autophagy, and invasion.

Main Results:

  • Rottlerin affects multiple cellular machineries, including survival, apoptosis, autophagy, and invasion.
  • The mechanisms of action are diverse, leading to cell-specific outcomes.
  • Rottlerin modulates signaling pathways at multiple levels.

Conclusions:

  • Rottlerin demonstrates significant potential as a chemotherapeutic agent due to its broad-spectrum activity.
  • Its ability to target multiple pathways simultaneously makes it an attractive candidate for cancer therapy.
  • Further research into Rottlerin's properties could lead to novel strategies for cancer prevention and treatment.

More Related Videos

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model09:03

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Published on: October 16, 2017

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...