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Published on: January 28, 2020
Sex differences in biomarkers for predicting cardiovascular and coronary events
Erjon Agushi1, Borejda Xhyheri, Raffaele Bugiardini
1Dipartimento di Medicina Interna, Cardioangiologia, Epatologia (Padiglione 11) University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. raffaele.bugiardini@unibo.it.
Insights
Cardiovascular disease biomarkers show sex differences. Understanding these differences in biomarker expression is crucial for developing tailored prevention and treatment strategies for men and women.
Area of Science:
- Cardiology
- Biochemistry
- Medical Research
Background:
- Cardiovascular disease (CVD) prevention is a key healthcare priority.
- Biomarkers are essential tools for CVD prevention.
- Cardiac disease presentation differs between men and women.
Purpose of the Study:
- To investigate potential sex differences in cardiovascular biomarker expression.
- To explore how these differences impact cardiac disease management.
Main Methods:
- Conducted a literature search of PubMed and Medline databases.
- Used keywords "Cardiovascular biomarkers sex differences".
- Reviewed studies comparing biomarker expression across genders in relation to cardiac events.
Main Results:
- Identified significant differences in biomarker expression levels between males and females.
- Observed variations in the role of specific biomarkers in cardiac events for each gender.
Conclusions:
- Sex-based differences in cardiovascular biomarker expression exist.
- Further research is warranted to elucidate these disparities.
- Findings may inform sex-specific CVD management approaches.
Introduction:
Primary and secondary prevention of cardiovascular Disease (CVD) are major concerns and priorities. The best tools that we actually have to prevent CVD are the biomarkers. Numerous studies have shown that the presentation of cardiac disease in women is quite different from the presentation in men. Thus, one question arises "Are there any differences in biomarkers as well?" The answer to this question could open new avenues for a tailored management of cardiac diseases.
Method And Results:
We searched the PubMed and Medline databases for articles comparing differences between the 2 genders in terms of biomarker expression. Keywords used included "Cardiovascular biomarkers sex differences". We reviewed the role of different biomarkers in the 2 genders in relation to cardiac events.
Conclusions:
Differences of expressions in biomarker levels were found between the 2 genders. Further investigation should be promoted.
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