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Adolescent experiences in a vaccine trial: a pilot study
Amber Abrams1, Nandi Siegfried, Hennie Geldenhuys
1South African Cochrane Centre/ South African Medical Research Council. amber.abrams@mrc.ac.za
Summary
Adolescents in a South African clinical trial reported positive experiences, motivated by altruism and healthcare access. Qualitative research within trials is feasible for understanding intervention acceptability.
Area of Science:
- Clinical research
- Adolescent health
- Qualitative research methods
Background:
- Limited understanding of adolescent experiences in clinical trials.
- Need for insight into participant perspectives and intervention acceptability.
Purpose of the Study:
- To assess the experiences of South African adolescents in a clinical trial.
- To explore motivations, challenges, and overall perceptions of trial participation.
Main Methods:
- Semi-structured interviews with adolescent participants.
- Qualitative data collection and analysis.
- Research conducted at a clinical trial site.
Main Results:
- Adolescents reported overall positive experiences despite some misunderstandings of consent and trial processes.
- Key motivations included altruism, healthcare access, and free health screenings.
- Initial fears regarding procedures like phlebotomy decreased over time.
Conclusions:
- Qualitative research within clinical trial settings is feasible.
- Adolescent participation in clinical trials can be positive and informative.
- Understanding participant experiences is crucial for intervention uptake and acceptability.
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