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Updated: May 25, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Active methylene-based multicomponent reactions under microwave heating
1Xuzhou Normal University, P.R. China. laotu@xznu.edu.cn
Abstract:
The use of emerging multicomponent reactions (MCRs) in conjunction with microwave (MW)-assisted chemistry techniques is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. MW-assisted active methylene-based multicomponent reactions serve as a rapid and efficient tool for the synthesis of versatile heterocycles, particularly those containing structural diversity and complexity via a one-pot operation. This minireview covers our recent advances on multicomponent reactions involving active methylene compounds for the construction of bioactive molecule skeletons. In many cases, MW-assisted MCRs offer considerable improvements in selectivity, chemical yield and purity and constitutes a very simple and extremely rapid method to access a diverse range of heterocyclic motifs.
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