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Published on: June 23, 2018
D-ribose in glycation and protein aggregation.
Yan Wei1, Chan Shuai Han, Jun Zhou
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China.
D-ribose contributes to protein aggregation and advanced glycation end products (AGEs) formation. This process, known as ribosylation, may link to cell dysfunction and cognitive impairments.
Area of Science:
- Biochemistry
- Cell Biology
- Neuroscience
Background:
- D-ribose is a fundamental pentose monosaccharide in all living cells.
- It is a component of vital biomolecules and metabolic pathways.
- D-ribose participates in protein glycation, forming advanced glycation end products (AGEs).
Purpose of the Study:
- To review the connection between ribosylation, protein aggregation, and cell death.
- To explore the role of D-ribose in cognitive impairments.
Main Methods:
- Literature review summarizing existing research.
- Analysis of the biochemical processes of ribosylation and glycation.
Main Results:
- D-ribose actively promotes protein glycation and aggregation.
- Ribosylation rapidly generates AGEs both in vitro and in vivo.
- Significant AGEs accumulation occurs intracellularly and extracellularly.
Conclusions:
- Ribosylation by D-ribose is implicated in cell dysfunction.
- This process may contribute to cognitive impairments.
- The review serves as a reference for D-ribose pharmacokinetics.
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