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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

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Polycystic kidney disease: a 2011 update

Theodore I Steinman1

  • 1Department of Medicine and Renal Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. tsteinma@bidmc.harvard.edu

Current Opinion in Nephrology and Hypertension
|January 26, 2012
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) research focuses on slowing cyst growth to preserve kidney function. Understanding total kidney volume and biomarkers aids in predicting disease progression and evaluating new treatments.

Area of Science:

  • Nephrology
  • Genetics
  • Molecular Biology

Background:

  • Polycystic kidney disease (PKD) is a common inherited disorder.
  • Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent form.
  • Research in PKD has significantly advanced in recent years.

Purpose of the Study:

  • To review clinically relevant advances in PKD, with a focus on ADPKD.
  • To discuss predicting ADPKD disease course.
  • To cover clinical trials and new research directions.

Main Methods:

  • Literature review of recent advances in PKD research.
  • Analysis of studies on cyst proliferation and fluid formation.
  • Examination of methods for predicting disease progression.

Main Results:

  • PKD research is highly active, focusing on pathophysiology.
  • Strategies aim to decrease cyst proliferation and fluid formation.
  • Preserving kidney function is linked to inhibiting cyst growth.

Conclusions:

  • Cysts are central to ADPKD; understanding this is key.
  • Total kidney volume and its relation to glomerular filtration rate predict disease course.
  • Biomarkers and managing complications are crucial for evaluating treatments and prognosis.
Abstract

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