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Developing a European grid infrastructure for cancer research: vision, architecture and services
M Tsiknakis1, S Rueping, L Martin
1Biomedical Informatics Laboratory, Institute of Computer Science, Foundation for Research & Technology-Hellas, GR-71110 Heraklion, Crete, Greece.
Ecancermedicalscience
|January 26, 2012
Summary
The ACGT project developed a European Biomedical Grid infrastructure to support advanced cancer clinical trials. This platform integrates multi-level clinical and genomic data for better disease understanding and patient stratification.
Area of Science:
- Biomedical Informatics
- Genomics
- Computational Biology
Background:
- Life sciences face an information revolution, with data generation outpacing analysis.
- Biomedical research requires robust data integration across diverse sources for R&D.
Purpose of the Study:
- To report on the design and development of the ACGT European Biomedical Grid infrastructure.
- To support multi-centric, post-genomic clinical trials for cancer research.
Main Methods:
- Defined user needs and scenarios for post-genomic clinical trials.
- Designed and presented an initial architecture with classified services.
- Developed a Master Ontology on sCancer as a core integration component.
Main Results:
- Established a legally compliant and trustworthy biomedical grid infrastructure.
- Integrated multi-level clinical and genomic data for advanced computational analysis.
- Facilitated hypothesis testing for identifying disease molecular drivers and patient stratification.
Conclusions:
- The ACGT infrastructure enables advanced, data-driven cancer clinical trials.
- The developed framework supports the integration and analysis of complex biomedical data.
- Future work will involve the broader cancer research community in utilizing the infrastructure.
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