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A User-friendly and Powerful R Analysis of Large-scale Datasets

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RhythmInsight: An Interactive Web Platform for Circadian and Diurnal Rhythmic Analysis and Visualization.

Guohao Han^1,2, Xiaodie Wu^1,2, Xiaoyun Xiao^1,2

¹Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, China.

Journal of Biological Rhythms

|May 6, 2026

Summary

RhythmInsight is a new web platform simplifying the analysis and visualization of circadian and diurnal rhythms. It offers 9 algorithms and interactive tools, making chronobiology research accessible to scientists without programming skills.

Keywords:

circadian rhythm data visualization differential rhythmicity analysis diurnal rhythm rhythmic analysis web server

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Area of Science:

Chronobiology
Computational Biology
Bioinformatics

Background:

Circadian and diurnal rhythms regulate physiological and behavioral processes.
The field of chronobiology is rapidly expanding in life sciences and translational medicine.
Existing computational tools for rhythm analysis are fragmented, require programming expertise, and have limited visualization capabilities.

Purpose of the Study:

To develop a comprehensive and user-friendly tool for detecting and analyzing circadian and diurnal rhythmicity.
To address the need for accessible rhythm analysis platforms for researchers without programming backgrounds.

Main Methods:

Development of RhythmInsight, an open-access, web-based platform.
Integration of 3 modules: Rhythmic Analysis (9 algorithms), Differential Rhythmicity Analysis (CircaCompare-based), and Rhythmic Visualization (plots, heatmaps, etc.).
Support for diverse data types including physiological, omics, and experimental data across species.

Main Results:

RhythmInsight provides a unified platform for rhythm detection, characterization, and comparison.
The platform integrates 9 established algorithms for robust rhythmic signal analysis.
Interactive visualization tools enhance the intuitive understanding of time-dependent trends.

Conclusions:

RhythmInsight simplifies complex chronobiological data analysis.
The platform enhances accessibility for experimental biologists and early-career scientists.
RhythmInsight facilitates the study of circadian and diurnal rhythms across various biological contexts.