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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Related Experiment Video

Updated: May 25, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

Cancer stem cells in melanoma.

C Regenbrecht1, Y Welte, R Hugel

  • 1Max Planck Institute for Molecular Genetics, Berlin, Germany. mail@christian-regenbrecht.de

Ecancermedicalscience
|January 26, 2012
PubMed
Summary
This summary is machine-generated.

Cancer stem cells may drive tumor growth and treatment resistance. Identifying and targeting these cells could lead to more effective cancer therapies.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Cancer stem cells (CSCs) are hypothesized to drive tumor growth, plasticity, and therapeutic resistance in various malignancies.
  • Melanoma stem cell markers such as CD133, CD166, Nestin, and BMI-1 have been identified in recent studies.
  • Understanding the origin and function of CSCs is crucial for advancing cancer treatment.

Purpose of the Study:

  • To explore the role of cancer stem cells in malignancy.
  • To review identified markers of melanoma stem cells.
  • To discuss the implications of CSCs for cancer therapy.

Main Methods:

  • Literature review of recent studies on cancer stem cells.
  • Analysis of identified melanoma stem cell markers (CD133, CD166, Nestin, BMI-1).
  • Discussion of the potential impact of CSCs on therapeutic strategies.

Main Results:

  • Cancer stem cells possess self-renewal capabilities and contribute to tumor plasticity.
  • Several markers are associated with melanoma stem cells, indicating their presence.
  • CSCs are implicated as a potential cause of ineffective conventional cancer therapies.

Conclusions:

  • Further research is needed to fully identify, define, and understand cancer stem cells.
  • If CSCs are confirmed to play a significant role, therapeutic strategies must be redirected.
  • Targeting cancer stem cells may offer a novel approach to overcome treatment failures in malignancy.