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Related Concept Videos

Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

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Related Experiment Video

Updated: May 25, 2026

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice
04:41

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice

Published on: February 24, 2026

ENaCs and ASICs as therapeutic targets.

Yawar J Qadri1, Arun K Rooj, Catherine M Fuller

  • 1Department of Physiology and Biophysics, University of Alabama at Birmingham, AL 35294, USA.

American Journal of Physiology. Cell Physiology
|January 27, 2012
PubMed
Summary
This summary is machine-generated.

Epithelial sodium channels (ENaC) and acid-sensitive ion channels (ASIC) are crucial for salt and water balance and have roles in hypertension, pain, and anxiety. Their widespread expression suggests broad therapeutic potential.

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Last Updated: May 25, 2026

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice
04:41

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice

Published on: February 24, 2026

Area of Science:

  • Physiology
  • Molecular Biology
  • Pharmacology

Background:

  • The epithelial sodium channel (ENaC) and acid-sensitive ion channel (ASIC) families are critical for ion transport.
  • Initially localized to epithelia and neurons, these channels are now known to be widely expressed.
  • Their dysregulation is implicated in various diseases.

Purpose of the Study:

  • To review the known and potential roles of ENaC and ASIC subunits in diverse pathologies.
  • To highlight therapeutic opportunities targeting these ion channels.
  • To discuss the fundamental importance of these channels in physiological and pathological processes.

Main Methods:

  • Literature review of studies on ENaC and ASIC channels.
  • Analysis of research on channel function in various tissues and disease models.
  • Synthesis of findings related to channel activity and disease pathogenesis.

Main Results:

  • ENaC plays a key role in salt and water homeostasis, relevant to hypertension (e.g., Liddle's syndrome).
  • ASIC activity is linked to neurological conditions such as anxiety disorders and pain.
  • The broad expression of these channels suggests involvement in numerous physiological and pathological contexts.

Conclusions:

  • ENaC and ASIC channels represent significant therapeutic targets for a range of conditions.
  • Understanding their ubiquitous expression and function is key to developing novel treatments.
  • Inappropriate channel activity underlies various diseases, emphasizing their clinical relevance.