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Updated: May 25, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid diseases and female reproduction.
G Mintziori1, P Anagnostis, K A Toulis
1Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Thyroid dysfunction impacts fertility and pregnancy outcomes. Treating thyroid issues can restore reproductive capacity and ensure healthy offspring development, highlighting the importance of thyroid health in women
Area of Science:
- Reproductive Endocrinology
- Thyroidology
Background:
- Thyroid disorders are prevalent in women of reproductive age.
- Normal thyroid function is vital for reproductive capacity.
- Thyroid dysfunction can reduce fertility and negatively impact pregnancy outcomes.
Purpose of the Study:
- To review current evidence on thyroid disorders in women seeking fertility, undergoing assisted reproduction technologies (ART), or pregnant.
- To elucidate the impact of thyroid status on reproductive outcomes and ART drugs on thyroid function.
- To highlight the importance of maternal thyroid health for fetal development and pregnancy.
Main Methods:
- Literature review of current evidence.
- Analysis of physiological and pathophysiological aspects.
- Examination of diagnostic and management strategies.
Main Results:
- Thyroid dysfunction can impair fertility and pregnancy.
- Assisted reproduction technologies (ART) require further investigation regarding their impact on thyroid function.
- Maternal thyroid function, including anti-thyroid antibodies, significantly affects pregnancy outcomes and fetal development.
Conclusions:
- Appropriate management of thyroid disorders can restore fertility.
- Maternal thyroid status is critical for successful conception, gestation, and fetal well-being.
- Further research is needed on ART's effects on thyroid function and vice versa.
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