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[Genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking
Yan Liu1, Xingxiang Li, Chaocai Wang
1Department of Toxicology, College of Public Health, Lanzhou University, Lanzhou 730000, China.
Objective:
To investigate the genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior.
Methods:
Polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) technique was used to detect the genotype of ADH3 and ALDH2. Drinking behavior was obtained by questionnaire.
Results:
The frequency of ADH3*2 and ALDH2*2 alleles in Tibetan population was 7.79% and 22.21% respectively, the frequency of ALDH2*2 and ADH3*1 alleles in non-drinkers was higher than that in drinkers, and the frequency of ALDH2*2 and ADH3*1 alleles in risk drinkers was lower than that in safe drinkers.
Conclusion:
ADH3 and ALDH2 are associated with drinking behavior in male Tibetan population.
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