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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Related Experiment Video

Updated: May 25, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Polymeric multilayer capsules for drug delivery.

Stefaan De Koker1, Richard Hoogenboom, Bruno G De Geest

  • 1Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.

Chemical Society Reviews
|January 28, 2012
PubMed
Summary
This summary is machine-generated.

Layer-by-Layer (LbL) assembly enables precise fabrication of polymeric multilayer capsules (PMLC) for advanced drug delivery. This review highlights engineering strategies for creating multifunctional drug carriers with tailored properties.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Layer-by-Layer (LbL) assembly is a versatile technique for creating multilayer thin films.
  • Polymeric multilayer capsules (PMLC) offer potential as sophisticated drug carriers.
  • Controlling physico-chemical properties is crucial for effective drug delivery.

Purpose of the Study:

  • To review recent advancements in PMLC for drug delivery applications.
  • To discuss how capsule engineering influences drug carrier properties.
  • To highlight the potential of PMLC in developing multifunctional drug carriers.

Main Methods:

  • Sequential adsorption of polymers onto spherical substrates.
  • Fabrication of multilayer thin films with controlled dimensions (10 nm to microns).
  • Analysis of PMLC properties for drug delivery suitability.

Main Results:

  • LbL assembly allows for precise control over PMLC fabrication.
  • Engineered PMLC exhibit unique properties suitable for drug carriers.
  • Recent advances focus on enhancing the functionality of these drug delivery systems.

Conclusions:

  • PMLC fabricated via LbL assembly represent a promising platform for drug delivery.
  • Sophisticated capsule engineering is key to designing effective and multifunctional drug carriers.
  • Further research in PMLC holds significant potential for therapeutic applications.