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Updated: May 25, 2026

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Published on: May 4, 2021
Update on exhaled nitric oxide in pulmonary disease
Naomi Spitale1, Nooreen Popat, Andrew McIvor
1Division of Respirology, Department of Medicine, The Ottawa Hospital, ON, Canada.
Measuring fraction of exhaled nitric oxide (FeNO) offers a noninvasive way to assess airway inflammation. While promising for asthma and other respiratory diseases, FeNO is currently best used as an adjunct to guide therapy, not for routine management.
Area of Science:
- Pulmonology
- Clinical Medicine
- Biochemistry
Background:
- Noninvasive assessment of airway inflammation is clinically desirable.
- Fraction of exhaled nitric oxide (FeNO) correlates with inflammation and is easily measured.
- FeNO shows potential for diagnostic and therapeutic roles in pulmonary diseases, especially asthma.
Purpose of the Study:
- To review the pathophysiology of nitric oxide.
- To outline FeNO measurement techniques.
- To explore the clinical applications of FeNO in asthma and other respiratory conditions.
Main Methods:
- Literature review of studies on nitric oxide and FeNO.
- Discussion of FeNO measurement principles.
- Analysis of clinical data regarding FeNO's utility.
Main Results:
- FeNO measurement is a noninvasive technique linked to airway inflammation.
- Studies suggest FeNO can aid in diagnosing and managing asthma.
- Ongoing research is exploring FeNO's role in various respiratory diseases.
Conclusions:
- FeNO holds promise for guiding asthma management and assessing future risk.
- Current evidence does not support routine clinical use of FeNO for all respiratory diseases.
- FeNO may serve as an adjuvant therapy guide for specific asthma and eosinophilic bronchitis cases.
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